診断薬技術開発研究室

室長  河 野 武 幸
(薬学博士)
研 究 概 要
生理活性物質,医薬品等の微量測定法の開発と体外医薬品としての実用化に関する研究を行っています.
主なテーマ
(1)骨代謝関連ホルモンの高感度酵素免疫測定法の開発とその応用
(2)免疫抑制剤の高感度酵素免疫測定法の開発とその応用
原 著 論 文 Matsumoto, N., Kohno, T., Uchida, S., Shimizu, T., Kusumoto, H.,Hirose, R., Yanada, K., Kurio, W., Yamaguchi, S., Watabe, K.,Fujita, T.: Preparation of antibodies against a novel
immunosuppressant, FTY720, and development of an enzyme
immunoassay for FTY720. Bioorg. Med. Chem., 14(12), 4182-4192
(2006).

Kohno, T., Tsuji, T., Hirayama, K., Iwatsuki, R., Hirose, M.,Watabe, K., Yoshikawa, H., Kohno, T., Matsumoto, A., Fujita, T.,Hayashi, M.: A novel immunomodulator, FTY 720, prevents
development of experimental autoimmune myasthenia gravis in
C57BL/6 mice. Biol. Pharm. Bull., 28(4), 736-739 (2005).

Kohno, T., Tsuji, T., Hirayama, K., Watabe, K., Matsumoto, A.,Kohno, T., Fujita, T.: A novel immunomodulator, FTY 720,prevents spontaneous dermatitis in NC/Nga mice. Biol. Pharm.
Bull., 27(9), 1392-1396 (2004).

Kohno, T., Kobashiri, Y., Sugie, Y., Takai, S., Watabe, K.,Kaino, Y., Kida, K.: Antibodies to Food Antigens in Japanese
Patients with Type-1 Diabetes Mellitus. Diabetes Res. Clin.
Prac., 55(1), 1-9 (2002).

Kohno, T., Tanaka, H., Watabe, K., Yamashita, S., Sezaki, H.,Nadai, T., Sugie, Y., Ogouchi, T.: Assessment of Mucosal
Immune Response in Genitourinary Tract Using Urine. Microbiol.
Immunol., 43(3), 253-258 (1999).

Kohno, T., Murasugi, N., Sakurai, H., Watabe, K., Nakamuta,H., Koida, M., Sugie, Y., Ogouchi, T., Inoue, T., Yanaka,M., Nomura, M., Yanagawa, A.: Determination of the
Bioavailability of Intranasal Elcatonin in Human: Development
of a Sandwich Transfer Enzyme Immunoassay for Elcatonin.
J. Clin. Lab. Anal., 12(6), 356-362 (1998).

Kohno, T., Murasugi, N., Sakurai, H., Watabe, K., Nakamuta,H., Kioda, M., Sugie, Y., Namura, M., Yanagawa, A.: Development
of a Highly Sensitive and Specific Two-Site Enzyme
Immunoassay for Parathyroid Hormone (1-34): Application
to Phamaco-kinetic Study on Intranasal Parathyroid
Hormone (1-34) in Human. J. Clin. Lab. Anal., 12(5),268-275 (1998).

Kohno, T., Murasugi, N., Sakurai, H., Watabe, K., Nakamuta,H., Koida, M., Sugie, Y., Nomura, M., Yanagawa, A.: A Sandwich
Transfer Enzyme Immunoassay for Salmon Calcitonin:
Determination of the Bioavailability of Intranasal Salmon
Calcitonin in Human. J. Clin. Lab. Anal., 11(6), 380-387 (1997).